[1] CHEN Q, WANG Q, ZHU J, et al. Reactive oxygen species:key regulators in vascular health and diseases[J]. Br J Pharmacol, 2018, 175(8):1279-1292.
[2] CHOI H Y, LEE J H, JEGAL K H, et al. Oxyresveratrol abrogates oxidative stress by activating Erk-Nrf2 pathway in the liver[J]. Chem Biol Interact, 2016, 245:110-121.
[3] TALEB A, AHMAD K A, IHSAN A U, et al. Antioxidant effects and mechanism of silymarin in oxidative stress induced cardiovascular diseases[J]. Biomed Pharmacother, 2018, 102:689-698.
[4] CADET J, DAVIES K J A. Oxidative DNA damage & repair: an introduction[J]. Free Radic Biol Med, 2017, 107:2-12.
[5] MENG P, YOSHIDA H, TANJI K, et al. Carnosic acid attenuates apoptosis induced by amyloid-beta 1-42 or 1-43 in SH-SY5Y human neuroblastoma cells[J]. Neurosci Res, 2015, 94:1-9.
[6] CHAE I G, YU M H, IM N K, et al. Effect of rosemarinus officinalisl. On MMP-9, MCP-1 levels, and cell migration in RAW 264.7 and smooth muscle cells[J]. J Med Food, 2012, 15(10):879-886.
[7] LIU K L, KUO W C, LIN C Y, et al. Prevention of 4-hydroxynonenal-induced lipolytic activation by carnosic acid is related to the induction of glutathione s-transferase in 3t3-l1 adipocytes[J]. Free Radic Biol Med, 2018, 121:1-8.
[8] SHAN W, GAO L, ZENG W, et al. Activation of the Sirt1/p66shc antiapoptosis pathway via carnosic acid-induced inhibition of miR-34a protects rats against nonalcoholic fatty liver disease[J]. Cell Death Dis, 2015, 6:e1833.
[9] KOCAK C, KOCAK F E, AKCILAR R, et al. Molecular and biochemical evidence on the protective effects of embelin and carnosic acid in isoproterenol-induced acute myocardial injury in rats[J]. Life Sci, 2016, 147:15-23.
[10] PARK M, HAN J, LEE C S, et al. Carnosic acid, a phenolic diterpene from rosemary, prevents uv-induced expression of matrix metalloproteinases in human skin fibroblasts and keratinocytes[J]. Exp Dermatol, 2013, 22(5):336-341.
[11] ALBALAWI A, ALHASANI R H A, BISWAS L, et al. Protective effect of carnosic acid against acrylamide-induced toxicity in RPE cells[J]. Food Chem Toxicol, 2017, 108:543-553.
[12] OU J, HUANG J, WANG M, et al. Effect of rosmarinic acid and carnosic acid on AGEs formation in vitro[J]. Food Chem, 2017, 221:1057-1061.
[13] LIN C, ZHANG X, XIAO J, et al. Effects on longevity extension and mechanism of action of carnosic acid in caenorhabditis elegans[J]. Food & Function, 2019, 10(3):1398-1410.
[14] TONG X P, MA Y X, QUAN D N, et al. Rosemary extracts upregulate Nrf2, Sestrin2, and MRP2 protein level in human hepatoma HepG2 cells[J]. Evid Based Complement Alternat Med, 2017, 2017:7359806.
[15] HAN N-N, ZHOU Q, HUANG Q, et al. Carnosic acid cooperates with tamoxifen to induce apoptosis associated with caspase-3 activation in breast cancer cells in vitro and in vivo[J]. Biomed Pharmacother, 2017, 89:827-837.
[16] ARMAGAN G, SEVGILI E, GURKAN F T, et al. Regulation of the Nrf2 pathway by glycogen synthase kinase-3beta in MPP(+)-induced cell damage[J]. Molecules, 2019, 24(7)pii:E1377.
[17] AHMED S M, LUO L, NAMANI A, et al. Nrf2 signaling pathway: pivotal roles in inflammation[J]. Biochim Biophys Acta, 2017, 1863(2):585-597.
[18] XIAO Q, PIAO R, WANG H, et al. Orientin-mediated Nrf2/HO-1 signal alleviates H₂O₂-induced oxidative damage via induction of JNK and PI3K/Akt activation[J]. Int J Biol Macromol, 2018, 118:747-755.
[19] LV H, LIU Q, ZHOU J, et al. Daphnetin-mediated Nrf2 antioxidant signaling pathways ameliorate tert-butyl hydroperoxide (t-BHP)-induced mitochondrial dysfunction and cell death[J]. Free Radic Biol Med, 2017, 106:38-52.
[20] SATOH T, KOSAKA K, ITOH K, et al. Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1[J]. J Neurochem, 2008, 104(4):1116-1131.
[21] SILVA J, ALVES C, PINTEUS S, et al. Neuroprotective effects of seaweeds against 6-hydroxidopamine-induced cell death on an in vitro human neuroblastoma model[J]. BMC Complement Altern Med, 2018, 18:58.
[22] CHEN J H, OU H P, LIN C Y, et al. Carnosic acid prevents 6-hydroxydopamine-induced cell death in SH-SY5Y cells via mediation of glutathione synthesis[J]. Chem Res Toxicol, 2012, 25(9):1893-1901.
[23] DE OLIVEIRA M R, FERREIRA G C, SCHUCK P F, et al. Role for the PI3K/Akt/Nrf2 signaling pathway in the protective effects of carnosic acid against methylglyoxal-induced neurotoxicity in SH-SY5Y neuroblastoma cells[J]. Chem Biol Interact, 2015, 242:396-406.
[24] MILLER D M, SINGH I N, WANG J A, et al. Nrf2-ARE activator carnosic acid decreases mitochondrial dysfunction, oxidative damage and neuronal cytoskeletal degradation following traumatic brain injury in mice[J]. Exp Neurol, 2015, 264:103-110.
[25] CAMPOCHIARO P A, MIR T A. The mechanism of cone cell death in retinitis pigmentosa[J]. Prog Retin Eye Res, 2018, 62:24-37.
[26] KANG K, TARCHICK M J, YU X, et al. Carnosic acid slows photoreceptor degeneration in the Pde6b(rd10) mouse model of retinitis pigmentosa[J]. Sci Rep, 2016, 6:22632.
[27] REZAIE T, MCKERCHER S R, KOSAKA K, et al. Protective effect of carnosic acid, a pro-electrophilic compound, in models of oxidative stress and light-induced retinal degeneration[J]. Invest Ophthalmol Vis Sci, 2012, 53(12):7847-7854.
[28] DING R B, BAO J, DENG C X. Emerging roles of Sirt1 in fatty liver diseases[J]. Int J Biol Sci, 2017, 13(7):852-867.
[29] DING M, HU L, YANG H, et al. Reduction of sirt1 blunts the protective effects of ischemic post-conditioning in diabetic mice by impairing the akt signaling pathway[J]. Biochim Biophys Acta Mol Basis Dis, 2019,1865(6):1677-1689.
[30] GAO L, SHAN W, ZENG W, et al. Carnosic acid alleviates chronic alcoholic liver injury by regulating the Sirt1/ChREBP and Sirt1/p66shc pathways in rats[J]. Mol Nutr Food Res, 2016, 60(9):1902-1911.
[31] NORIEGA L G, FEIGE J N, CANTO C, et al. CREB and ChREBP oppositely regulate Sirt1 expression in response to energy availability[J]. EMBO Rep, 2011, 12(10):1069-1076.
[32] KONG X, GUAN J, LI J, et al. P66(shc)-Sirt1 regulation of oxidative stress protects against cardio-cerebral vascular disease[J]. Mol Neurobiol, 2017, 54(7):5277-5285.
[33] YUAN Y, WANG H, WU Y, et al. P53 contributes to cisplatin induced renal oxidative damage via regulating p66shc and MnSOD[J]. Cell Physiol Biochem, 2015, 37(4):1240-1256.
[34] ZAKHARI S. Overview:how is alcohol metabolized by the body[J]. Alcohol Res Health, 2006, 29(4):245-254.
[35] WANG R H, LI C, DENG C X. Liver steatosis and increased ChREBP expression in mice carrying a liver specific Sirt1 null mutation under a normal feeding condition[J]. Int J Biol Sci, 2010, 6(7):682-690.
[36] GOURANTON E, ROMIER B, MARCOTORCHINO J, et al. Visfatin is involved in TNFα-mediated insulin resistance via an NAD(+)/Sirt1/PTP1B pathway in 3T3-L1 adipocytes[J]. Adipocyte, 2014, 3(3):180-189.
[37] JIAO D, ZHANG H, JIANG Z, et al. MicroRNA-34a targets sirtuin 1 and leads to diabetes-induced testicular apoptotic cell death[J]. J Mol Med (Berl), 2018, 96(9):939-949.
[38] LI J S, CHEN Z Y, HONG W. Effect of vitamin E on the expression of SIRT1 and PGC-1α in mice with nonalcoholic fatty liver disease[J]. Chin Pharm J (中国药学杂志), 2017, 52(12):1029-1033.
[39] WANG T, TAKIKAWA Y. Carnosic acid protects normal mouse hepatocytes against H₂O₂-induced cytotoxicity via sirtuin 1-mediated signaling[J]. Hepatol Res, 2016, 46(2):239-246.
[40] DAHL T B, HOLM S, AUKRUST P, et al. Visfatin/NAMPT: a multifaceted molecule with diverse roles in physiology and pathophysiology[J]. Annu Rev Nutr, 2012, 32:229-243.
[41] ZHAO Y, SHI X, DING C, et al. Carnosic acid prevents COL1A2 transcription through the reduction of Smad3 acetylation via the AMPKα1/Sirt1 pathway[J]. Toxicol Appl Pharmacol, 2018, 339:172-180.
[42] HE Y, FENG D, LI M, et al. Hepatic mitochondrial DNA/Toll-like receptor 9/MicroRNA-223 forms a negative feedback loop to limit neutrophil overactivation and acetaminophen hepatotoxicity in mice[J]. Hepatology, 2017, 66(1):220-234.
[43] CHANG S H, MORI D, KOBAYASHI H, et al. Excessive mechanical loading promotes osteoarthritis through the gremlin-1-nf-κb pathway[J]. Nat Commun, 2019, 10(1):1442.
[44] LI C, CHEN T, ZHOU H, et al. Schisantherin a attenuates neuroinflammation in activated microglia: role of Nrf2 activation through ERK phosphorylation[J]. Cell Physiol Biochem, 2018, 47(5):1769-1784.
[45] WU Z, WANG Y, MENG X, et al. Total c-21 steroidal glycosides, isolated from the root tuber of cynanchum auriculatum royle ex wight, attenuate hydrogen peroxide-induced oxidative injury and inflammation in l02 cells[J]. Int J Mol Med, 2018, 42(6):3157-3170.
[46] LI Z W, HUANG J J, YANG W H. Interactive molecular mechanism between Nrf2 and NF-κB pathways in drug induced liver injury[J]. Chin Pharm J(中国药学杂志), 2018, 53(9):666-670.
[47] YU Y M, LIN H C, CHANG W C. Carnosic acid prevents the migration of human aortic smooth muscle cells by inhibiting the activation and expression of matrix metalloproteinase-9[J]. Br J Nutr, 2008, 100(4):731-738.
[48] YU Y M, LIN C H, CHAN H C, et al. Carnosic acid reduces cytokine-induced adhesion molecules expression and monocyte adhesion to endothelial cells[J]. Eur J Nutr, 2009, 48(2):101-106.
[49] LIU M, ZHOU X, ZHOU L, et al. Carnosic acid inhibits inflammation response and joint destruction on osteoclasts, fibroblast-like synoviocytes, and collagen-induced arthritis rats[J]. J Cell Physiol, 2018, 233(8):6291-6303.
[50] XIA G, WANG X, SUN H, et al. Carnosic acid (CA) attenuates collagen-induced arthritis in db/db mice via inflammation suppression by regulating ROS-dependent p38 pathway[J]. Free Radic Biol Med, 2017, 108:418-432.
[51] VAN DOOREN F E, POUWER F, SCHALKWIJK C G, et al. Advanced glycation end product (AGE) accumulation in the skin is associated with depression: the maastricht study[J]. Depress Anxiety, 2017, 34(1):59-67.
[52] WANG Z Q, JING L L, YAN J C, et al. Role of AGEs in the progression and regression of atherosclerotic plaques[J]. Glycoconj J, 2018, 35(5):443-450.
[53] LIN C Y, TSAI C W. Carnosic acid attenuates 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells by inducing autophagy through an enhanced interaction of Parkin and Beclin1[J]. Mol Neurobiol, 2017, 54(4):2813-2822.
[54] HAN G E, KANG H T, CHUNG S, et al. Novel neohesperidin dihydrochalcone analogue inhibits adipogenic differentiation of human adipose-derived stem cells through the Nrf2 pathway[J]. Int J Mol Sci, 2018, 19(8):2215.
[55] GAYA M, REPETTO V, TONEATTO J, et al. Antiadipogenic effect of carnosic acid, a natural compound present in Rosmarinus officinalis, is exerted through the C/EBPs and PPARγ pathways at the onset of the differentiation program[J]. Biochim Biophys Acta, 2013, 1830(6):3796-3806.
[56] PARK M Y, SUNG M K. Carnosic acid inhibits lipid accumulation in 3T3-L1 adipocytes through attenuation of fatty acid desaturation[J]. J Cancer Prev, 2015, 20(1):41-49.
[57] TSAI C W, LIU K L, LIN Y R, et al. The mechanisms of carnosic acid attenuates tumor necrosis factor-α-mediated inflammation and insulin resistance in 3T3-L1 adipocytes[J]. Mol Nutr Food Res, 2014, 58(4):654-664.